There are definitely ways to get back into the work world after a long absence. You could look into freelancing from home on a site like Upwork. If you're good at writing, editing, photography, computer stuff, graphics, art, teaching (especially language) or even if you are good at office work or making audios or videos there are tons of freelance jobs you can get. That will beef up your resume' so that you can apply for better jobs later.
You could also start some great entry level jobs, like doing taxes, working with the post office, working in childcare, etc. Are you interested in doing some kind of training prior to starting a new career or do you want to start something that will train you or that you can learn on the job?